01
Heart Health
PREDIMED Trial
Journal: New England Journal of Medicine
Year: 2018
Summary: A landmark randomized clinical trial showing that a Mediterranean diet supplemented with extra virgin olive oil significantly reduced the risk of major cardiovascular events.
Read Original Study https://www.nejm.org/doi/full/10.1056/NEJMoa1800389
Lyon Diet Heart Study
Journal: Circulation
Year: 1999
Summary: Demonstrated that a Mediterranean dietary pattern significantly reduced recurrent heart attacks and improved long-term cardiovascular outcomes.
Read Original Study https://www.ahajournals.org/doi/10.1161/01.CIR.99.6.733
CORDIOPREV Trial
Journal: The Lancet
Year: 2022
Summary: Found that a Mediterranean diet rich in extra virgin olive oil provided greater protection against recurrent cardiovascular events than a low-fat diet.
Read Original Study https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00122-2/fulltext
02
Brain Function
PREDIMED-NAVARRA Cognitive Study
Journal: Journal of Neurology, Neurosurgery & Psychiatry
Year: 2013
Summary: Participants following a Mediterranean diet enriched with extra virgin olive oil showed better cognitive performance than those on a low-fat diet.
Read Original Study https://pubmed.ncbi.nlm.nih.gov/23670794/
Mediterranean Diet and Age-Related Cognitive Decline
Journal: JAMA Internal Medicine
Year: 2015
Summary: Reported improved memory and cognitive function among older adults consuming a Mediterranean diet enriched with extra virgin olive oil.
Read Original Study https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2293082
Olive Oil Consumption and Dementia-Related Death
Journal: JAMA Network Open
Year: 2024
Summary: Higher olive oil intake was associated with a lower risk of dementia-related mortality, independent of overall diet quality.
Read Original Study https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818362
03
Cellular Protection
EU Health Claim – Olive Oil Polyphenols
Source: European Commission
Year: 2012
Summary: The EU recognizes that olive oil polyphenols help protect blood lipids from oxidative stress when consumed in sufficient quantities.
Read Original Study https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6431
Oleocanthal: Ibuprofen-like Activity in Extra Virgin Olive Oil
Journal: Nature
Year: 2005
Summary: Identified oleocanthal as a naturally occurring olive oil compound with anti-inflammatory activity similar to ibuprofen.
Read Original Study https://www.nature.com/articles/437045a
Biological Activities of Phenolic Compounds Present in Virgin Olive Oil
Journal: International Journal of Molecular Sciences
Year: 2010
Summary: Reviewed evidence showing that olive oil phenolic compounds contribute to antioxidant defence and healthy cellular function.
Read Original Study https://pmc.ncbi.nlm.nih.gov/articles/PMC2852848/
04
Gut Health
Extra Virgin Olive Oil and the Gut-Brain Axis
Journal: Nutrition Reviews
Year: 2021
Summary: Reviewed evidence suggesting that extra virgin olive oil may positively influence the gut microbiome and gut-brain communication.
Read Original Study https://academic.oup.com/nutritionreviews/article/79/12/1362/6133931
Dietary EVOO Polyphenols and Gut Microbiota Interaction
Journal: Foods
Year: 2022
Summary: Demonstrated that olive oil polyphenols can promote beneficial gut bacteria and support a healthier intestinal environment.
Read Original Study https://pmc.ncbi.nlm.nih.gov/articles/PMC9495659/
Mediterranean Diet Enriched with High-Quality EVOO and Gut Microbiota
Journal: Frontiers in Pharmacology
Year: 2019
Summary: Reported that a Mediterranean diet rich in extra virgin olive oil was associated with improvements in gut microbial diversity and metabolic health.
Read Original Study https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.01366/full
05
Longevity & Wellbeing
Olive Oil Consumption and Risk of Total and Cause-Specific Mortality
Journal: Journal of the American College of Cardiology
Year: 2022
Summary: Higher olive oil intake was associated with lower risks of all-cause, cardiovascular, cancer, and neurodegenerative disease mortality.
Read Original Study https://www.jacc.org/doi/10.1016/j.jacc.2021.10.041
Olive Oil Intake and Mortality in the EPIC-Spain Cohort
Journal: American Journal of Clinical Nutrition
Year: 2012
Summary: Long-term olive oil consumption was associated with reduced overall mortality in a large Mediterranean population cohort.
Read Original Study https://pubmed.ncbi.nlm.nih.gov/22648725/
PREDIMED Trial
Journal: New England Journal of Medicine
Year: 2018
Summary: Long-term adherence to a Mediterranean diet supplemented with extra virgin olive oil was associated with significant improvements in cardiovascular health and overall wellbeing.
Read Original Study https://www.nejm.org/doi/full/10.1056/NEJMoa1800389